反应详情

A mixture of ethyl (E)-3-(1-benzyl-3-benzyloxy-1H-pyrazol-4-yl)propenoate (14.30 g), 5% palladium-carbon (28.00 g), ethanol (150 ml) and tetrahydrofuran (150 ml) was stirred under a hydrogen atmosphere at room temperature for 3 hrs. Palladium-carbon was filtered off and the filtrate was concentrated. The obtained crystals were collected by filtration to give ethyl 3-(1-benzyl-3-hydroxy-1H-pyrazol-4-yl)propionate (9.01 g, yield 83%). The crystals were recrystallized from ethyl acetate-hexane. melting point: 75–76° C.

1. filtrationPalladium-carbon was filtered off
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration