反应详情

A mixture of 3-benzyloxy-1-phenyl-1H-pyrazol-4-ylmethyl acetate (2.35 g), 5% palladium-carbon (4.00 g), tetrahydrofuran (25 ml) and methanol (25 ml) was stirred under a hydrogen atmosphere for 1 hr. Palladium-carbon was filtered off and the filtrate was concentrated to give methyl 3-hydroxy-1-phenyl-1H-pyrazol-4-ylacetate (1.58 g, yield 93%) as colorless crystals. The crystals were recrystallized from ethyl acetate-hexane. melting point: 144–145° C.

1. filtrationPalladium-carbon was filtered off
2. concentrationthe filtrate was concentrated