1,2,3,6-Tetrahydropyridine → HCID 9815869, compound

HRID 1295384Notes

Reaction equation

HRID 1295384 reaction equation
[NH:1]1[CH2:6][CH:5]=[CH:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]=[C:15]=[O:16])=[CH:10][CH:9]=1>O1CCCC1>[F:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([N:1]2[CH2:2][CH:3]=[CH:4][CH2:5][CH2:6]2)=[O:16])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 127501,2,3,6-TetrahydropyridineHCID 709554-Fluorophenyl isocyanate

Product 1

HCID 9815869HCID 9815869, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 1,2,3,6-tetrahydropyridine (82 mg) in tetrahydrofuran (2 ml) was added 4-fluorophenyl-isocyanate (0.112 ml) at ambient temperature. After stirring at ambient temperature for 10 hours, the solvent was removed by evaporation under reduced pressure, and the residue was triturated with diisopropyl ether to give 1-(4-fluorophenylcarbamoyl)-1,2,3,6-tetrahydropyridine (117 mg).

Workup

  1. customthe solvent was removed by evaporation under reduced pressure
  2. customthe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-650adbd113104fea97468e7a89dcf70a
Source dataset
uspto-grants-2007_07
Patent number
US07241811B2

Reaction notes

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