HuagongsheHuagongshe Chemistry Print Report · For research reference only
3'-Acetamido-2-bromoacetophenone → 4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3'-Acetamido-2-bromoacetophenone | HCID 12431847 | — |
| Reactant | [4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide | HCID 69511913 | — |
| Product | 4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline | HCID 9944394 | — |
Reaction Steps
Starting from 2,4-dichlorobenzylmethylamine (Example 1, intermediate 1) and N-[3-(2-bromoacetyl)phenyl]acetamide (cf. Example 1, intermediate 2), the aniline derivative 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (cf. Example 1, intermediate 6) was prepared in a similar manner to the synthetic route described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241775B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-49cc90ade7cd4173844a4f99eb7db0dd |
| Source note | uspto-grants-2007_07 |