Hydrochloric Acid → HCID 69511493, compound

HRID 1295430Notes

Reaction equation

HRID 1295430 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:32])[C@H:22]([OH:31])[C@@H:23]([OH:30])[C@H:24]([OH:29])[C@H:25]([OH:28])[CH2:26][OH:27].Cl>O>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:32])[C@H:22]([OH:31])[C@@H:23]([OH:30])[C@H:24]([OH:29])[C@H:25]([OH:28])[CH2:26][OH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11488611HCID 11488611, compound2×

Product 1

HCID 69511493HCID 69511493, compoundYield 190.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

145.5 mg (0.3 mmol) of N-[2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-2,3,4,5,6-pentahydroxygluconamide (example compound 3) were taken up in 75 ml of H2O and admixed at room temperature with 3.0 ml of 0.1 M HCl. The mixture was stirred for 15 minutes, filtered and freeze-dried to obtain 149 mg of the desired hydrochloride.

Workup

  1. filtrationfiltered
  2. customfreeze-dried

Sources & evidence

ORD record
ord-826c1f10768849539c24a389d198bfe4
Source dataset
uspto-grants-2007_07
Patent number
US07241775B2

Reaction notes

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