4-Nitrophenyl chloroformate → 3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline

Participants

Role	Name	HCID	Charge
Reactant	4-Nitrophenyl chloroformate	HCID 82129	—
Reactant	[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide	HCID 69511913	—
Product	3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline	HCID 9836194	—

Reaction Steps

1.54 g (5.0 mmol) of enantiomer B of intermediate 1 were reacted with 1.1 equivalents of 4-nitrophenyl chloroformate in a similar manner to the method described in Example 6, intermediate 1 to obtain 1.87 g of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07241775B2
Source dataset	uspto-grants-2007_07
ORD ID	ord-93fef47868a3494bb6ae53e9d7e78830
Source note	uspto-grants-2007_07