反应详情

A mixture of 6-iodo-1H-quinolin-2-one (6.23 g, 23 mmol) in phosphorus oxychloride (25 mL) was refluxed under N2 for 2 h. After cooling, the solvent was removed by rotary evaporator and then by the oil pump. Sat. sodium bicarbonate (100 mL) was slowly added. The solid was collected by filtration, washed with sat. sodium bicarbonate, water and dried to obtain 2-chloro-6-iodo-quinoline (5.78 g, 87%) as a black solid. LC-MS m/e 290 (MH+).

1. temperaturewas refluxed under N2 for 2 h
2. temperatureAfter cooling
3. customthe solvent was removed by rotary evaporator
4. additionSat. sodium bicarbonate (100 mL) was slowly added
5. filtrationThe solid was collected by filtration
6. washwashed with sat. sodium bicarbonate, water
7. customdried