反应详情

温度

140 °C

A suspension of 2-chloro-6-iodo-quinoline (1 g, 3.46 mmol) in ammonium hydroxide (28%, 20 mL) was heated at 140° C. for 3 days under pressure tube. After cooling, the solvent was removed by rotary evaporator. The solid was collected by filtration, washed with water and dried to obtain 6-iodo-quinolin-2-ylamine (0.78 g, 84%) as a black solid. LC-MS m/e 271 (MH+).

1. temperatureAfter cooling
2. customthe solvent was removed by rotary evaporator
3. filtrationThe solid was collected by filtration
4. washwashed with water
5. customdried