HRID1295471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15719

3-Methoxyphenylacetic acid

C9H10O3

HCID70487

tetra-Aminopyrimidine

C4H8N6

HCID111544

4,5,6-Pyrimidinetriamine, sulfate (1:1)

C4H9N5O4S

HCID179502

2-(2-Methoxyphenyl)acetyl chloride

C9H9ClO2

HCID4323424

2-fluoro-7H-purine

C5H3FN4

PRODUCTS

生成物

HCID5289228

未命名化合物

HCID67230252

未命名化合物

PROCEDURE

实验过程

9-Butyl-8-(2-methoxy-benzyl)-9H-purin-6-ylamine and 9-butyl-8-(3-methoxy-benzyl)-9H-purin-6-ylamine were prepared from 4,5,6-triaminopyrimidine sulfate and, respectively 2-methoxyphenyl acetyl chloride or 3-methoxyphenyl acetic acid, by procedures analogous to the one described above. 2-Fluoro purine analogs were also prepared from 2,4,5,6-tetraaminopyrimidine, by procedures analogous to those described above. See Example 2, step 4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8586363e89944167952c27c8c0fa2c50
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07241890B2
来源说明: uspto-grants-2007_07

反应 SMILES

S(O)(O)(=O)=O.[NH2:6][C:7]1[C:12]([NH2:13])=[C:11]([NH2:14])[N:10]=[CH:9][N:8]=1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH2:23][C:24](Cl)=O.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH2:35][C:36](O)=O)[CH:32]=[CH:33][CH:34]=1.FC1N=C2C(NC=N2)=CN=1.N[C:50]1[N:55]=[C:54]([NH2:56])[C:53]([NH2:57])=[C:52]([NH2:58])[N:51]=1>>[CH2:30]([N:6]1[C:24]([CH2:23][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[O:16][CH3:15])=[N:13][C:12]2[C:7]1=[N:8][CH:9]=[N:10][C:11]=2[NH2:14])[CH2:29][CH2:34][CH3:33].[CH2:20]([N:58]1[C:36]([CH2:35][C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([O:28][CH3:27])[CH:30]=2)=[N:57][C:53]2[C:52]1=[N:51][CH:50]=[N:55][C:54]=2[NH2:56])[CH2:21][CH2:22][CH3:17]