HRID1295515

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

HCID12991620

N-[tert-Butoxy(hydroxy)methylidene]-2-methylserine

C9H17NO5

HCID69265594

未命名化合物

PRODUCTS

产物

HCID86605701

未命名化合物

收率 66.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID81531

Diisopropylethylamine

C8H19N

PROCEDURE

实验过程

This compound was synthesized from 2-(4-(4-nitrophenoxy)butyl)thiophene (280 mg), N-(Boc)-α-methylserine (205 mg), HATU (442 mg), and DIPEA (506 μl) following the procedure described in Example 5(A) to yield 280 mg product (62% yield). 1H NMR (400 MHz, DMSO-d6) δ 9.24 (s, 1H), 7.44 (m, 2H), 7.29 (m, 1H), 6.9 (m, 1H), 6.84–6.81 (m, 3H), 5.00 (t, 1H), 3.93 (t, 2H), 3.61 (m, 2H), 2.84 (t, 2H), 1.73 (m, 4H), 1.48 (overlapping singlets, 9H).