反应详情

6-Methyl-3,4-dihydro-2H-benzo[1,4]oxazine (1.49 g, 10 mmol) was dissolved in dichloromethane (50 mL) and treated with triethylamine (1.14 g, 11 mmol) followed by the dropwise addition of methanesulfonyl chloride (1.26 g, 11 mmol). The mixture was stirred at ambient temperature for 18 h then evaporated to dryness under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The phases were separated and the organic phase washed with water, saturated brine, dried (MgSO4) and evaporated to dryness under reduced pressure to give the title compound (2.09 g, 93%) as a brown solid.

1. customthen evaporated to dryness under reduced pressure
2. customThe residue was partitioned between ethyl acetate and saturated aqueous NaHCO3
3. customThe phases were separated
4. washthe organic phase washed with water, saturated brine
5. dry with materialdried (MgSO4)
6. customevaporated to dryness under reduced pressure