Hydrochloric Acid → HCID 22326677, compound

HRID 1295581Notes

Reaction equation

HRID 1295581 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]3[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=3[CH:25]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>ClCCl>[ClH:26].[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]3[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=3[CH:25]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57575834HCID 57575834, compound

Product 1

HCID 22326677HCID 22326677, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of 6-(1-(tert-butyloxycarbonyl)piperidin-4-yloxy)-4H-benzo[1,4]oxazin-3-one (3.78 g, 10.9 mmol), ethereal hydrogen chloride (50 mL) and dichloromethane (20 mL) was heated at 40° C. for 2 h, then allowed to stir at 20° C. for 18 h. The resulting colourless solid was collected by filtration to give the title compound (2.72 g, 88%).

Workup

  1. filtrationThe resulting colourless solid was collected by filtration

Sources & evidence

ORD record
ord-291284446d704972bafe6a199429988c
Source dataset
uspto-grants-2007_07
Patent number
US07244726B2

Reaction notes

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