1-butylindole-3-carboxylic Acid → 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-yl(hydroxy)methyl}-1H-indole-3-carboxylic acid

HRID 129559Notes

Reaction equation

HRID 129559 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[CH:6]1)[CH2:2][CH2:3][CH3:4].[CH3:17][C:18]([N:26]1[N:30]=[N:29][C:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:37]2[CH:42]=[CH:41][C:40]([CH:43]=[O:44])=[CH:39][CH:38]=2)=[N:27]1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:19]>>[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:6]1[CH:43]([C:40]1[CH:39]=[CH:38][C:37]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:28]2[N:29]=[N:30][N:26]([C:18]([CH3:19])([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH3:17])[N:27]=2)=[CH:42][CH:41]=1)[OH:44])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 103762901-butylindole-3-carboxylic AcidHCID 15225578HCID 15225578, compound

Product 1

HCID 193719071-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-yl(hydroxy)methyl}-1H-indole-3-carboxylic acid

Procedure

reacting the 2-lithiated 1-butyl-1H-indole-3-carboxylic acid with protected 2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-carbaldehyde to give 1-butyl-2-{2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl-4-yl(hydroxy)methyl}-1H-indole-3-carboxylic acid;

Sources & evidence

ORD record
ord-ed105e98f4694dc2b9f27d917f14e861
Source dataset
uspto-grants-1995_11
Patent number
US05468867

Reaction notes

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