Isobutyraldehyde → HCID 23105919, compound

HRID 1295602Notes

Reaction equation

HRID 1295602 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.[Mg].[CH:14](=[O:18])[CH:15]([CH3:17])[CH3:16]>>[CH3:16][CH:15]([CH3:17])[CH:14]([C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1)[OH:18]

Participants

4

Reactant 3

HCID 6561IsobutyraldehydeHCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 5462224Magnesium

Product 1

HCID 23105919HCID 23105919, compound

Procedure

The target compound is obtained analogously to method described for Example 1a). First of all a Grignard is prepared from 23.7 g (96 mmol) 1-bromo-4-(trifluoromethoxy)-benzene and 2.35 g (97 mmol) magnesium, which is then reacted with 7.3 g (100 mmol) isobutyraldehyde. After working up and purification by column chromatography 14.8 g of a brown oil are obtained which is further reacted directly.

Workup

  1. customThe target compound is obtained analogously to method
  2. custompurification by column chromatography 14.8 g of a brown oil
  3. customare obtained which
  4. customis further reacted directly

Sources & evidence

ORD record
ord-0a48a6be273a4ccd8d6514b82e26bc4c
Source dataset
uspto-grants-2007_07
Patent number
US07244728B2

Reaction notes

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