Trifluoroacetate → HCID 46232857, compound

HRID 1295603Notes

Reaction equation

HRID 1295603 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:20](=[O:26])[CH:21](OCC)O)[C:12]2[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=2[CH:19]=1)C1C=CC=CC=1.[CH3:27][C:28]([NH2:42])([CH3:41])[CH2:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][C:37]([F:40])([F:39])[F:38])=[CH:32][CH:31]=1.FC(F)(F)C([O-])=O>>[CH3:41][C:28]([NH:42][CH2:21][CH:20]([C:11]1[C:12]2[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=2[CH:19]=[C:9]([OH:8])[CH:10]=1)[OH:26])([CH3:27])[CH2:29][C:30]1[CH:31]=[CH:32][C:33]([O:36][C:37]([F:38])([F:39])[F:40])=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 22063474HCID 22063474, compoundHCID 23105931HCID 23105931, compound

Product 1

HCID 46232857HCID 46232857, compound

Procedure

The target compound is obtained by reacting 357 mg (1 mmol) 6-benzyloxy-8-(2-ethoxy-2-hydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one with 233 mg (1 mmol) 1,1-dimethyl-2-(4-trifluoromethoxy-phenyl)-ethylamine using the method described for Example 2c). Beige solid. Yield: 279 mg (50%, trifluoroacetate); mass spectroscopy: [M+H]+=441.

Workup

  1. customThe target compound is obtained

Sources & evidence

ORD record
ord-7c532280b1ae466c9d1e5ca05426797d
Source dataset
uspto-grants-2007_07
Patent number
US07244728B2

Reaction notes

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