反应详情

8.00 g (42 mmol) 1-(4-chloro-2-trifluoromethyl-phenyl)-2-methyl-propan-1-ol and 2.5 g p-toluenesulphonic acid monohydrate in 200 mL toluene are refluxed overnight, while the water formed is captured using a water separator. The reaction mixture is left to cool, combined with water and the organic phase is separated off. It is extracted with toluene and the organic phases are combined and evaporated down. The residue is added to a short silica gel column and eluted with hexane. Colourless oil.

1. customformed
2. waitThe reaction mixture is left
3. temperatureto cool
4. customthe organic phase is separated off
5. extractionIt is extracted with toluene
6. customevaporated down
7. additionThe residue is added to a short silica gel column
8. washeluted with hexane