Trifluoroacetate → HCID 46232973, compound

HRID 1295609Notes

Reaction equation

HRID 1295609 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:20](=[O:26])[CH:21](OCC)O)[C:12]2[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=2[CH:19]=1)C1C=CC=CC=1.Cl[C:28]1[CH:33]=[CH:32][C:31]([CH2:34][C:35]([NH2:38])([CH3:37])[CH3:36])=[C:30]([C:39]([F:42])([F:41])[F:40])[CH:29]=1.FC(F)(F)C([O-])=O>>[CH3:37][C:35]([NH:38][CH2:21][CH:20]([C:11]1[C:12]2[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=2[CH:19]=[C:9]([OH:8])[CH:10]=1)[OH:26])([CH3:36])[CH2:34][C:31]1[CH:32]=[CH:33][CH:28]=[CH:29][C:30]=1[C:39]([F:40])([F:41])[F:42]

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 22063474HCID 22063474, compoundHCID 67133248HCID 67133248, compound

Product 1

HCID 46232973HCID 46232973, compound

Procedure

357 mg (1 mmol) 6-benzyloxy-8-(2-ethoxy-2-hydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 252 mg (1 mmol) 2-(4-chloro-2-trifluoromethyl-phenyl)-1,1-dimethyl-ethylamine are reacted and worked up analogously to the method described for Example 2c). White solid. Yield: 165 mg (31%, trifluoroacetate); mass spectroscopy [M+H]+=425.

Sources & evidence

ORD record
ord-1d06af81ac9843609e46612a2d2bf817
Source dataset
uspto-grants-2007_07
Patent number
US07244728B2

Reaction notes

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