HCID 58909205, compound → HCID 58909203, compound

HRID 1295615Notes

Reaction equation

HRID 1295615 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[C:16](Br)[O:17][C:11]=2[N:10]=[C:9]1[CH:19]([NH:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH2:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[CH:16][O:17][C:11]=2[N:10]=[C:9]1[CH:19]([NH:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH2:20][CH3:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 58909205HCID 58909205, compound

Product 1

HCID 58909203HCID 58909203, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 3-benzyl-6-bromo-2-(1-{[2-(dimethylamino)-ethyl]amino}propyl)furo[2,3-d]pyrimidin-4(3H)-one (1-5, 1 equiv) and 10% Pd/C in ethanol is hydrogenated at 1 atm. for 3 h. The mixture is filtered and the filtrate is concentrated to provide 3-benzyl-2-(1-{[2-(dimethylamino)ethyl]amino}propyl)-furo[2,3-d]pyrimidin4(3H)-one (1-6)

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-5843e24403c849648715a23ae8191868
Source dataset
uspto-grants-2007_07
Patent number
US07244723B2

Reaction notes

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