反应详情

A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for 5 hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. temperatureThe reaction mixture then was cooled
4. customAnhydrous hydrochloric acid was bubbled into the mixture
5. customa white precipitate formed
6. filtrationThe precipitate was collected by suction filtration
7. washwashed repeatedly with diethyl ether
8. customDrying