反应详情

A solution of 4-dimethoxymethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl (2.9 g, 7.0 mmol) and 15 mL of 4M hydrochloric acid in 50 mL of methanol was stirred at room temperature for 18 hours. The mixture was diluted with 200 mL of diethyl acetate and poured into 300 mL of water. The ethyl acetate layer was washed 3 times with water, dried over magnesium sulfate and concentrated giving a white, waxy solid (2.51 g). A portion of the solid (1.53 g) was crystallized from diethyl ether and isolated. Drying gave 2'-[2-(1-methyl-1-phenylethyl)biphenyl-2H-tetrazolebiphenyl-4-carbaldehyde (1.2 g, 3.2 mmol), m.p. 98.5°-97° C.

1. washThe ethyl acetate layer was washed 3 times with water
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated