HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 10382358, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3,5-Difluorophenol | HCID 75928 | — |
| Reactant | Diamide | HCID 5353800 | — |
| Reactant | 2-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol | HCID 11416074 | — |
| Product | HCID 10382358 | HCID 10382358 | — |
Reaction Steps
The title compound was prepared according to the general procedure described above starting from TMAD (384 mg, 2.25 mmol), 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy]ethanol (600 mg, 1.86 mmol), triphenylphosphine (969 mg, 3.69 mmol), 3,5-difluorophenol (239 mg, 1.84 mmol). Yield: 123 mg (20%); mp 119-121° C. HRMS m/z calcd for C16H18F2N4O2 (M)+ 336.1398, found 336.1409.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244722B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-2ce8c233591e46c0bce3c8fa760dc0e7 |
| Source note | uspto-grants-2007_07 |