Triphenylphosphine → HCID 10382358, compound

HRID 1295696Notes

Reaction equation

HRID 1295696 reaction equation
CN(C(/N=N/C(N(C)C)=O)=O)C.C(OC([N:20]1[CH2:25][CH2:24][N:23]([C:26]2[C:27]([O:32]CCO)=[N:28][CH:29]=[CH:30][N:31]=2)[CH2:22][CH2:21]1)=O)(C)(C)C.[C:36]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C[CH:37]=1.[F:55][C:56]1[CH:57]=[C:58]([OH:63])[CH:59]=[C:60]([F:62])[CH:61]=1>>[F:55][C:56]1[CH:57]=[C:58]([CH:59]=[C:60]([F:62])[CH:61]=1)[O:63][CH2:36][CH2:37][N:28]1[CH:29]=[CH:30][N:31]=[C:26]([N:23]2[CH2:22][CH2:21][NH:20][CH2:25][CH2:24]2)[C:27]1=[O:32]

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 759283,5-DifluorophenolHCID 5353800DiamideHCID 114160742-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol

Product 1

HCID 10382358HCID 10382358, compound

Procedure

The title compound was prepared according to the general procedure described above starting from TMAD (384 mg, 2.25 mmol), 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-pyrazinyloxy]ethanol (600 mg, 1.86 mmol), triphenylphosphine (969 mg, 3.69 mmol), 3,5-difluorophenol (239 mg, 1.84 mmol). Yield: 123 mg (20%); mp 119-121° C. HRMS m/z calcd for C16H18F2N4O2 (M)+ 336.1398, found 336.1409.

Sources & evidence

ORD record
ord-2ce8c233591e46c0bce3c8fa760dc0e7
Source dataset
uspto-grants-2007_07
Patent number
US07244722B2

Reaction notes

Loading…