HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, (2-bromoethoxy)- → 3-[4-(2-Phenoxyethyl)piperazin-1-yl]-1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, (2-bromoethoxy)- | HCID 68526 | — |
| Reactant | 2(1H)-Pyrazinone, 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]- | HCID 10405848 | — |
| Reactant | 3-(1-Piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone, Hydrochloride | HCID 11639709 | — |
| Product | 3-[4-(2-Phenoxyethyl)piperazin-1-yl]-1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one, Hydrochloride | HCID 131726526 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 60 starting from 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone (0.35 g, 1.0 mmol; from the free base of Example 3) and 2-bromoethyl phenyl ether (0.22 g, 1.1 mmol). Yield 0.14 g (27%). HPLC purity: 99%. HRMS calc for C24H25F3N4O3 (M)+ 474.1879, found 474.1887.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244722B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-6e039fa45a634fc4a843a88994f3e7ad |
| Source note | uspto-grants-2007_07 |