HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 3-(4-Benzylpiperazin-1-yl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 2(1H)-Pyrazinone, 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]- | HCID 10405848 | — |
| Reactant | 3-(1-Piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone, Hydrochloride | HCID 11639709 | — |
| Product | 3-(4-Benzylpiperazin-1-yl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]pyrazin-2(1H)-one hydrochloride | HCID 10435302 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 60 starting from 3-(1-piperazinyl)-1-[2-(2,4,5-trifluorophenoxy)ethyl]-2(1H)-pyrazinone (0.35 g, 1.0 mmol; from the free base of Example 3) and benzyl bromide (0.19 g, 1.1 mmol) Yield: 0.17 g (35%); HPLC purity: 99%; mp 214-214.5° C. HRMS calc for C23H23F3N4O2 (M)+ 444.1773, found 444.1789.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244722B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-33b9381be5ad40ca9f2e1fe044a466b6 |
| Source note | uspto-grants-2007_07 |