反应详情

TBDMSCl silylation reagent in DMF (60 mL) was added to 3-(2-hydroxy-ethoxy)-benzaldehyde (4.985 g, 30.00 mmol). The mixture was stirred at room temperature for 72 h. The mixture was diluted with water and extracted with diethyl ether. The ethereal extracts were dried over Na2SO4 and concentrated in vacuo. The residue was purified by SiO2 eluted with 95:5 CH2Cl2/MeOH to give 2.38 g (28%) of a clear oil.

1. extractionextracted with diethyl ether
2. dry with materialThe ethereal extracts were dried over Na2SO4
3. concentrationconcentrated in vacuo
4. customThe residue was purified by SiO2
5. washeluted with 95:5 CH2Cl2/MeOH