Diisopropylethylamine → Quinazolino-pyridine

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1-(4-Chloropyridin-2-YL)-N-methylmethanamine	HCID 55252951	—
Reactant	2-chloro-5,6,7-trimethoxy-1H-quinazolin-4-one	HCID 178486898	—
Solvent	Ethanol	HCID 702	—
Product	Quinazolino-pyridine	HCID 69507823	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

Diisopropylethylamine (0.15 mL, 0.86 mmol) was added to a mixture of 2-chloro-5,6,7-trimethoxy-1H-quinazolin-4-one (0.2 g, 0.78 mmol) and 4-chloro-2-methylaminomethylpyridine (0.13 g, 0.86 mmol) in EtOH (8 mL). The mixture was heated at 90° C. for 5 h. After cooling, the resulting white solid was filtered and washed with MeOH to provide quinazolino-pyridine compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07244738B2
Source dataset	uspto-grants-2007_07
ORD ID	ord-518ec43289d94ba7999cb0a5d13c2efe
Source note	uspto-grants-2007_07