Diisopropylethylamine → Quinazolino-pyridine

HRID 1295743Notes

Reaction equation

HRID 1295743 reaction equation
C(N(C(C)C)CC)(C)C.Cl[C:11]1[NH:12][C:13]2[C:18]([C:19](=O)[N:20]=1)=[C:17](OC)[C:16](OC)=[C:15](OC)[CH:14]=2.Cl[C:29]1C=C[N:32]=[C:31](CNC)[CH:30]=1>CCO>[CH:19]1[C:18]2[C:17]3[CH:29]=[CH:30][CH:31]=[N:32][C:16]=3[CH:15]=[CH:14][C:13]=2[N:12]=[CH:11][N:20]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 552529511-(4-Chloropyridin-2-YL)-N-methylmethanamineHCID 1784868982-chloro-5,6,7-trimethoxy-1H-quinazolin-4-one

Product 1

HCID 69507823Quinazolino-pyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Diisopropylethylamine (0.15 mL, 0.86 mmol) was added to a mixture of 2-chloro-5,6,7-trimethoxy-1H-quinazolin-4-one (0.2 g, 0.78 mmol) and 4-chloro-2-methylaminomethylpyridine (0.13 g, 0.86 mmol) in EtOH (8 mL). The mixture was heated at 90° C. for 5 h. After cooling, the resulting white solid was filtered and washed with MeOH to provide quinazolino-pyridine compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting white solid was filtered
  3. washwashed with MeOH

Sources & evidence

ORD record
ord-518ec43289d94ba7999cb0a5d13c2efe
Source dataset
uspto-grants-2007_07
Patent number
US07244738B2

Reaction notes

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