5-Amino-2-methylphenol → HCID 10198953, compound

HRID 1295746Notes

Reaction equation

HRID 1295746 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:15]3=[CH:16][C:17](C)=[CH:18][N:14]3[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].O[C:21]1C=C(C=CC=1C)N>>[OH:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:15]3=[CH:16][CH:17]=[C:18]([CH3:21])[N:14]3[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 178185-Amino-2-methylphenolHCID 10131256HCID 10131256, compound

Product 1

HCID 10198953HCID 10198953, compound

Procedure

Example 11 was prepared as a white solid in 30% overall yield from Compound E using the 2 step sequence of Compound A of Example 1 and Compound B of Example 1, using 3-hydroxy-4-methylaniline. The product was purified by flash chromatography on silica with 25% ethyl acetate/hexanes. (M+H)+ 255.

Workup

  1. customExample 11 was prepared as a white solid in 30%
  2. customThe product was purified by flash chromatography on silica with 25% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-16f9ff3543b34605a1f41963c359223f
Source dataset
uspto-grants-2007_07
Patent number
US07244733B2

Reaction notes

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