反应详情

A solution of 3.45 g of L-tartaric acid (1.07 eq.) in 56 g of water was added to a flask containing a slurry of 8.00 g of the product of Example 41G in anhydrous ethanol (44 g). The mixture was heated under reflux and after 30 minutes most solids had dissolved. The mixture was cooled at 5° C. per hour to 60° C., and then allowed to cool to ambient temperature overnight. After cooling the mixture to −15° C. the product slurry was filtered and dried at 45-50° C. overnight to provide the title compound (10.64 g, 94.8%).

1. temperatureThe mixture was heated
2. temperatureunder reflux and after 30 minutes most solids
3. dissolutionhad dissolved
4. temperatureThe mixture was cooled at 5° C. per hour to 60° C.
5. temperatureAfter cooling the mixture to −15° C. the product slurry
6. filtrationwas filtered
7. customdried at 45-50° C. overnight