反应详情

A mixture of 2-bromobenzaldehyde (100 g; 0.54 mol), ethylene glycol (67.03 g; 1.08 mol), p-toluenesulphonic acid (0.5 g) and toluene was heated to and maintained at reflux temperature for 6 hours. During this period, water/ethylene glycol (23 ml) was removed by azeotropic distillation. The mixture was cooled and ether (1 l) was added. The ether solution was washed with saturated sodium bicarbonate solution (200 ml) water (3×150 ml) and saturated brine (1×150 ml). After drying and filtration, evaporation of the ether solution gave 2-(2-bromophenyl)-1,3-dioxolane (121.96 g, 98.6% yield) as an oil.

1. temperaturewas heated to and
2. temperaturemaintained
3. temperatureat reflux temperature for 6 hours
4. waitDuring this period
5. customwater/ethylene glycol (23 ml) was removed by azeotropic distillation
6. temperatureThe mixture was cooled
7. additionether (1 l) was added
8. washThe ether solution was washed with saturated sodium bicarbonate solution (200 ml) water (3×150 ml) and saturated brine (1×150 ml)
9. customAfter drying
10. filtrationfiltration, evaporation of the ether solution