反应详情

(1-Benzhydryl-pyrrolidin-3-ylmethyl)methyl carbamic acid-tert-butyl ester (0.47 g, 1.67 mmol) was dissolved in dry CH2Cl2 (15 ml) followed by addition of TFA (8 ml). The resulting solution was stirred at r.t. for 2 hrs. The solution was concentrated under reduced pressure. The resulting residue was dissolved in water (12 ml) and pH of the solution was adjusted to 10. The water phase was extracted with CH2Cl2 (100 ml), and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give the desired product in almost quantitative yield.

1. concentrationThe solution was concentrated under reduced pressure
2. dissolutionThe resulting residue was dissolved in water (12 ml)
3. extractionThe water phase was extracted with CH2Cl2 (100 ml)
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated under reduced pressure