Methylamine → 3-Hydroxy-N-methyl-5-(trifluoromethyl)benzamide

HRID 1295909Notes

Reaction equation

HRID 1295909 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5](O)=[O:6].[CH3:15][NH2:16]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([NH:16][CH3:15])=[O:6]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 27831463-hydroxy-5-(trifluoromethyl)benzoic Acid

Product 1

HCID 674156453-Hydroxy-N-methyl-5-(trifluoromethyl)benzamide

Procedure

Prepared from 3-hydroxy-5-(trifluoromethyl)benzoic acid and methylamine using the method of preparation 58 to give the title compound as a pale orange solid.

Workup

  1. customthe method of preparation 58

Sources & evidence

ORD record
ord-36781dc215ab4413b683e33e21324ba7
Source dataset
uspto-grants-2007_07
Patent number
US07244766B2

Reaction notes

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