反应详情

After adding 10% palladium-carbon (50% wet) (100 mg) to a solution of 1-[3-(tert-butyl)-4-hydroxy-5-nitrophenyl]-1-ethanone (1.00 g, 4.22 mmol) in ethyl acetate (10 ml) at room temperature, the mixture was hydrogenated for 3 hours under normal pressure. The 10% palladium-carbon was then filtered through celite and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel chromatography (Wakogel-C200,10 g) to yield the title compound (627 mg, 71.8% yield) as a light red powder from the ethyl acetate-hexane (1:4˜1:3) fraction.

1. filtrationThe 10% palladium-carbon was then filtered through celite
2. distillationthe solvent was distilled off under reduced pressure