反应详情

After dissolving ethyl 5-bromo-2-ethoxy-4-methylbenzoate (19.72 g) in carbon tetrachloride, azobisisobutyronitrile (1.13 g) was added and the mixture was heated to reflux for 30 minutes. N-bromosuccinimide was added and the mixture was further heated to reflux for 1 hour. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (10.54 g) as a colorless oil.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 30 minutes
4. temperaturethe mixture was further heated
5. temperatureto reflux for 1 hour
6. filtrationThe reaction mixture was filtered
7. concentrationthe filtrate was concentrated
8. customThe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)