反应详情

After dissolving the N1-methyl-4-(aminomethyl)-5-bromo-2-ethoxybenzamide (6.77 g) in pyridine (50 ml), 4-nitrobenzenesulfonyl chloride (5.3 g) was added and the mixture was stirred at room temperature overnight. Water and ethyl acetate were then added for separation. The organic layer was washed with 1 N hydrochloric acid and brine and the precipitated crystals were filtered out (5.57 g). The organic layer of the filtrate was dried over anhydrous magnesium sulfate, filtered and concentrated and the residue was washed with ethyl acetate and filtered. A total of 8.31 g of the title compound was obtained as a white solid.

1. additionwas added
2. washThe organic layer was washed with 1 N hydrochloric acid and brine
3. filtrationthe precipitated crystals were filtered out (5.57 g)
4. dry with materialThe organic layer of the filtrate was dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. washthe residue was washed with ethyl acetate
8. filtrationfiltered