反应详情

(7-Thiocyanato-indan-4-yloxy)-acetic acid methyl ester (Example 1C) (3.09 g, 12.9 mmol) was dissolved in 30 ml methanol. Dithiothreitol (2.6 g) was added followed by sodium borohydride (200 mg). The reaction was stirred for 1 hour followed by concentration to an oil. The crude product was dissolved in 200 ml dichloromethane and filtered through silica gel and eluted with 200 ml dichloromethane. The product was then recrystallized from ethyl acetate/heaxanes to afford the title product. MS m/z 239 (M+1).

1. concentrationfollowed by concentration to an oil
2. dissolutionThe crude product was dissolved in 200 ml dichloromethane
3. filtrationfiltered through silica gel
4. washeluted with 200 ml dichloromethane
5. customThe product was then recrystallized from ethyl acetate/heaxanes