4-Hydroxybenzyl Alcohol → HCID 16641047, compound

HRID 1296038Notes

Reaction equation

HRID 1296038 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Cl[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[F:19][C:18]([F:20])([F:21])[C:15]1[CH:16]=[CH:17][C:12]([CH2:11][O:9][C:6]2[CH:7]=[CH:8][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 1254-Hydroxybenzyl AlcoholHCID 10796Cesium carbonateHCID 123096p-Trifluoromethylbenzyl chloride

Product 1

HCID 16641047HCID 16641047, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Hydroxymethyl-phenol (1 g, 8.06 mmol), 1-Chloromethyl-4-trifluoromethyl-benzene (1.57 g, 8.06 mmol), and cesium carbonate (5.26 g, 16.12 mmol) were refluxed in acetonitrile for 20 h, cooled, filtered, and concentrated to give the title compound. MS m/z 265 (M−H2O+1).

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-310c376259344908ab9161dd7e368a59
Source dataset
uspto-grants-2007_07
Patent number
US07244763B2

Reaction notes

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