反应详情

Compound 69B was suspended in 100 ml dichloromethane. SOCl2 was added and allowed to stir for 2 h. 20 ml Saturated sodium bicarbonate was added followed by 20 ml water and stirred for 5 minutes. The dichloromethane layer was seperated and dried over anhydrous sodium sulfate. The dichloromethane solution was filtered through silica and eluted with dichloromethane until clear. Concentration of the filtrate gave a pink solid. MS m/z 262 (M+1).

1. stirringstirred for 5 minutes
2. customThe dichloromethane layer was seperated
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationThe dichloromethane solution was filtered through silica
5. washeluted with dichloromethane until clear
6. customConcentration of the filtrate gave a pink solid