(6-Hydroxy-benzo[b]thiophen-3-yl)acetic acid methyl ester → HCID 69514708, compound

HRID 1296063Notes

Reaction equation

HRID 1296063 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=3)=[N:8][C:7]=2[CH:18]=1.[CH3:19][O:20][C:21](=[O:33])[CH2:22][C:23]1[C:24]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][C:25]=2[S:26][CH:27]=1>>[CH3:19][O:20][C:21](=[O:33])[CH2:22][C:23]1[C:24]2[CH:31]=[CH:30][C:29]([O:32][CH2:2][C:3]3[CH:4]=[CH:5][C:6]4[O:10][C:9]([C:11]5[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=5)=[N:8][C:7]=4[CH:18]=3)=[CH:28][C:25]=2[S:26][CH:27]=1

Participants

3

Reactant 2

HCID 20765985(6-Hydroxy-benzo[b]thiophen-3-yl)acetic acid methyl esterHCID 22504861HCID 22504861, compound

Product 1

HCID 69514708HCID 69514708, compound

Procedure

Compound 69C and Compound 5C were reacted in a manner analogous to Compound 59A to give {6-[2-(3-Fluoro-phenyl)-benzooxazol-5-ylmethoxy]-benzo[b]thiophen-3-yl}-acetic acid methyl ester. This was reacted in a manner analogous to Compound 59 to give the title product. 400 MHz 1H NMR (DMSO-d6) δ ppm 3.7 (s, 2H) 5.3 (s, 2H) 7.1 (dd, J=8.8, 2.4 Hz, 1H) 7.3 (s, 1H) 7.5 (m, 1H) 7.5 (dd, J=8.3, 1.7 Hz, 1H) 7.6 (m, 3H) 7.8 (d, J=8.3 Hz, 1H) 7.9 (m, 2H) 8.0 (dt, J=8.1, 1.1 Hz, 1H).

Sources & evidence

ORD record
ord-fdf70c7a2c1f4fbb94f44ec573aedbfd
Source dataset
uspto-grants-2007_07
Patent number
US07244763B2

Reaction notes

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