Trifluoroacetic acid → Trifluoroacetic acid

HRID 1296162Notes

Reaction equation

HRID 1296162 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[CH:10][C:9]=1[CH3:20])(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[CH2:18]([N:15]([CH2:16][CH3:17])[C:11]1[CH:10]=[C:9]([CH3:20])[C:8]([NH2:7])=[CH:13][C:12]=1[CH3:14])[CH3:19].[C:24]([OH:26])([C:23]([F:28])([F:27])[F:22])=[O:25]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66758160HCID 66758160, compound

Product 2

HCID 6422Trifluoroacetic acidYield 100%HCID 437491HCID 437491, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 41 in 2 mL dichoromethane, trifloroacetic acid (1 mL) was added. The reaction mixture was stirred for 2 h. At this point, LC-MS showed the reaction to be complete. The reaction was concentrated to remove the solvent and most of the TFA. The residue was then dried further in a high vacuum oven over 24 h to give the title compound 42 as TFA salt (100% yield).

Workup

  1. customthe reaction
  2. concentrationThe reaction was concentrated
  3. customto remove the solvent
  4. customThe residue was then dried further in a high vacuum oven over 24 h

Sources & evidence

ORD record
ord-daceb442aafa45ccb156391b2cfe5992
Source dataset
uspto-grants-2007_07
Patent number
US07244739B2

Reaction notes

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