反应详情

13.0 g of 2-methoxybenzylamine was dissolved in 80 ml of tetrahydrofuran, and tetrahydrofuran solution (20 ml) containing 16 g of t-butyldicarbonate was added, followed by stirring for 1 hour at room temperature. The solvent was evaporated, and the residue was dissolved in ethyl acetate and successively washed with 1 N hydrochloric acid and saturated brine. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated, to give 19.0 g of t-butyl N-(2-methoxybenzyl)carbamate.

1. additionwas added
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in ethyl acetate
4. washsuccessively washed with 1 N hydrochloric acid and saturated brine
5. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
6. customthe solvent was evaporated