2-{[(Benzyloxy)carbonyl]amino}-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)-2-propenoic acid methyl ester → Methyl 2-amino-3-(3-[(tert-butoxycarbonyl)amino]methyl-4-methoxyphenyl)propanoate

Participants

Reaction Steps

4.09 g of 2-{([(benzyloxy)carbonyl]amino}-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)-2-propenoic acid methyl ester was dissolved in 50 ml of methanol and 20 ml of tetrahydrofuran. 0.41 g of 10% palladium carbon was added, followed by stirring for 64 hours at room temperature in hydrogen atmosphere. The catalyst was removed by filtration and washed with ethyl acetate. The filtrate was evaporated, to give 2.92 g of (2-amino)-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)propionic acid methyl ester as a colorless oil.

Provenance & Evidence