Hydrochloric Acid → HCID 86597538, compound

HRID 1296233Notes

Reaction equation

HRID 1296233 reaction equation
C(OC([N:8]1[CH2:37][CH2:36][N:11]2[C:12](=[O:35])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][C:20]=1[CH3:30])=[CH:15][C:14]=3[C:31]([F:34])([F:33])[F:32])=O)(C)(C)C.[ClH:38]>C(OCC)C>[ClH:38].[CH3:30][C:20]1[CH:21]=[C:22]([O:25][C:26]([F:27])([F:28])[F:29])[CH:23]=[CH:24][C:19]=1[C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:35])[N:11]3[CH2:36][CH2:37][NH:8][CH2:9][C@H:10]32)=[C:14]([C:31]([F:34])([F:32])[F:33])[CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86597539HCID 86597539, compound

Product 1

HCID 86597538HCID 86597538, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(2-methyl-4-trifluoromethoxyphenyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (11 mg, 0.022 mmol) was added diethyl ether (2 mL) and saturated aqueous hydrochloric acid (1 mL). After 15 min of stirring, the reaction was concentrated, diluted with water and lyopholized to give (R)-1,3,4,10b-tetrahydro-9-(2-methyl-4-trifluoromethoxyphenyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one hydrochloric acid salt (9.7 mg, 97%) as a white solid. MS (ESI) 431.3 (M−Cl).

Workup

  1. concentrationthe reaction was concentrated
  2. additiondiluted with water

Sources & evidence

ORD record
ord-9f9685cf16e046868783bc652c8a7687
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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