Hydrochloric Acid → HCID 11346774, compound

HRID 1296244Notes

Reaction equation

HRID 1296244 reaction equation
C(OC([N:8]1[CH2:24][CH2:23][N:11]2[C:12](=[O:22])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[Cl:21])=O)(C)(C)C.Cl>>[ClH:21].[Cl:21][C:14]1[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[C:18]2[C:13]=1[C:12](=[O:22])[N:11]1[CH2:23][CH2:24][NH:8][CH2:9][C@H:10]12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68689389HCID 68689389, compound

Product 1

HCID 11346774HCID 11346774, compound

Procedure

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-7-chloro-9-methoxy-pyrazino[2,1-a]isoindol-6(2H)-one (16 mg, 0.05 mmol) was added concentrated aqueous hydrochloric acid (1 mL, 12N). After 1 min, the solution was concentrated, diluted with water, and lyopholized to give a white solid (13 mg, quant). MS (ESI) 253.2, 255.2 (M−Cl).

Workup

  1. concentrationthe solution was concentrated
  2. additiondiluted with water
  3. customto give a white solid (13 mg, quant)

Sources & evidence

ORD record
ord-a627540745834f118e6a81b80e002887
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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