Hydrochloric Acid → HCID 11163457, compound

HRID 1296247Notes

Reaction equation

C(OC([N:8]1[CH2:28][CH2:27][N:11]2[C:12](=[O:26])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([CH2:19][CH2:20][CH3:21])=[CH:15][C:14]=3[C:22]([F:25])([F:24])[F:23])=O)(C)(C)C.[ClH:29]>>[ClH:29].[CH2:19]([C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:26])[N:11]3[CH2:27][CH2:28][NH:8][CH2:9][C@H:10]32)=[C:14]([C:22]([F:24])([F:25])[F:23])[CH:15]=1)[CH2:20][CH3:21]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68691468HCID 68691468, compound

Product 1

HCID 11163457HCID 11163457, compoundYield 89%

Procedure

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-propyl-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (25 mg, 0.06 mmol) was added concentrated aqueous hydrogen chloride (1 mL). After 5 min, the solution was concentrated, diluted with water, and lyopholized to give the desired product as an off-white solid (19 mg, 89%). %). MS (ESI) 299.3 (M−Cl).

Workup

concentrationthe solution was concentrated
additiondiluted with water

Sources & evidence

ORD record: ord-6f48c37a60394cf4bc3004099bc9bae1
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07244843B2

Reaction notes

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