Hydrochloric Acid → HCID 11253484, compound

HRID 1296249Notes

Reaction equation

HRID 1296249 reaction equation
C(OC([N:8]1[CH2:22][CH2:21][N:11]2[C:12](=[O:20])[C:13]3[C:18]([CH:10]2[CH2:9]1)=[CH:17][CH:16]=[CH:15][C:14]=3[OH:19])=O)(C)(C)C.[ClH:23]>>[ClH:23].[OH:19][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:13]=1[C:12](=[O:20])[N:11]1[CH2:21][CH2:22][NH:8][CH2:9][CH:10]12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68688831HCID 68688831, compound

Product 1

HCID 11253484HCID 11253484, compoundYield 42%

Procedure

To N-(t-butoxycarbonyl)-(±)-1,3,4,10b-tetrahydro-7-hydroxy-pyrazino[2,1-a]isoindol-6(2H)-one (24 mg, 0.08 mmol) was added concentrated aqueous hydrogen chloride (1 mL). After 5 min, the solution was concentrated, diluted with water, and lyopholized to give the desired product as an off-white solid (8 mg, 42%). MS (ESI) 205.2 (M−Cl).

Workup

  1. concentrationthe solution was concentrated
  2. additiondiluted with water

Sources & evidence

ORD record
ord-a026b89111604d25b7148a6d84ada22e
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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