Hydrochloric Acid → HCID 11186350, compound

HRID 1296255Notes

Reaction equation

HRID 1296255 reaction equation
C(OC([N:8]1[CH2:26][C@@H:25]([CH3:27])[N:11]2[C:12](=[O:24])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21])=O)(C)(C)C.[ClH:28]>CCOCC.O>[ClH:28].[CH3:27][C@H:25]1[N:11]2[C:12](=[O:24])[C:13]3[C:18]([C@@H:10]2[CH2:9][NH:8][CH2:26]1)=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68690065HCID 68690065, compound

Product 1

HCID 11186350HCID 11186350, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(4R,10bR)-1,3,4,10b-tetrahydro-4-methyl-7-trifluoromethoxy-pyrazino[2,1-a]isoindol-6(2H)-one(30 mg, 0.08 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 21 mg of a white solid. MS (ESI) 271 (M−Cl).

Sources & evidence

ORD record
ord-3036a5f3e4ba477aa8a1685d6539287c
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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