Hydrochloric Acid → HCID 11187602, compound

HRID 1296263Notes

Reaction equation

HRID 1296263 reaction equation
C(OC([N:8]1[CH2:30][CH2:29][N:11]2[C:12](=[O:28])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([CH:19]([CH2:22][CH3:23])[CH2:20][CH3:21])=[CH:15][C:14]=3[C:24]([F:27])([F:26])[F:25])=O)(C)(C)C.[ClH:31]>CCOCC.O>[ClH:31].[CH3:23][CH2:22][CH:19]([C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:28])[N:11]3[CH2:29][CH2:30][NH:8][CH2:9][C@H:10]32)=[C:14]([C:24]([F:26])([F:27])[F:25])[CH:15]=1)[CH2:20][CH3:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68691525HCID 68691525, compound

Product 1

HCID 11187602HCID 11187602, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(3-pentyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (35 mg, 0.08 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 25 mg of a white solid. MS (ESI) 327 (M−Cl).

Sources & evidence

ORD record
ord-1c7be8bb62184dca9d054dabcd5d870f
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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