Hydrochloric Acid → HCID 11336078, compound

HRID 1296272Notes

Reaction equation

HRID 1296272 reaction equation
C(OC([N:8]1[CH2:27][CH2:26][N:11]2[C:12](=[O:25])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([C:19]#[CH:20])=[CH:15][C:14]=3[C:21]([F:24])([F:23])[F:22])=O)(C)(C)C.[ClH:28]>CCOCC.O>[ClH:28].[C:19]([C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:25])[N:11]3[CH2:26][CH2:27][NH:8][CH2:9][C@H:10]32)=[C:14]([C:21]([F:23])([F:24])[F:22])[CH:15]=1)#[CH:20]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86597540HCID 86597540, compound

Product 1

HCID 11336078HCID 11336078, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-ethynyl-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (27 mg, 0.8 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 22 mg of a white solid. MS (ESI) 281 (M−Cl).

Sources & evidence

ORD record
ord-7ce6f582139d4dc18d9a5d3c838263c4
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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