HRID1296365

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

HCID312

Chloride

Cl-

HCID674

Dimethylamine

C2H7N

HCID9321

Hydrazine

H4N2

结构：O=C(O)C12CC3CC(O)(C1)CC(C(=O)O)(C3)C2

HCID12010644

未命名化合物

PRODUCTS

生成物

HCID365222

未命名化合物

结构：COC(=O)C12CC3CC(C1)CC(C(=O)N(C)C)(C3)C2

HCID18410477

未命名化合物

PROCEDURE

实验过程

For example, reaction of 1,3-dicarboxy-5-adamantanol with ammonia provides 1,3-dicarbamoyl-5-admatanol. Reaction of 1,3-dicarboxy-5,7-adamantanediol with hydrazine forms 1,3-di(hydrazinocarbonyl)-5,7-adamantanediol, etc. 1-(N,N-dimethylcarbamoyl)-3-adamantanol can be obtained by acting thyonyl chloride on 1-carboxy-3-adamantanol followed by reacting the resultant compound with dimethylamine. Similarly, 1-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane can be formed from 1-carboxy-3-methoxycarbonyladamantane,

WORKUP

后处理

customprovides 1,3-dicarbamoyl-5-admatanol
customcan be obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e86830847fe746a4b465f2229ec6e9f9
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: USRE039744E1
来源说明: uspto-grants-2007_07

反应 SMILES

[C:1]([C:4]12[CH2:13][C:8]3(O)[CH2:9][CH:10]([CH2:12][C:6]([C:15]([OH:17])=[O:16])([CH2:7]3)[CH2:5]1)[CH2:11]2)(O)=O.N.[C:19]([C:22]12[CH2:32][C:26]3(O)[CH2:27][C:28](O)([CH2:30][C:24]([C:34]([OH:36])=[O:35])([CH2:25]3)[CH2:23]1)[CH2:29]2)([OH:21])=[O:20].NN.N(C(C12CC3(O)CC(O)(CC(C(NN)=O)(C3)C1)C2)=O)N.[CH3:59][N:60]([CH3:74])[C:61](C12CC3CC(CC(O)(C3)C1)C2)=[O:62].[Cl-].CNC>>[CH3:59][N:60]([CH3:74])[C:61]([C:8]12[CH2:13][CH:4]3[CH2:11][CH:10]([CH2:12][C:6]([C:15]([O:17][CH3:19])=[O:16])([CH2:5]3)[CH2:7]1)[CH2:9]2)=[O:62].[C:19]([C:22]12[CH2:32][CH:26]3[CH2:27][CH:28]([CH2:30][C:24]([C:34]([O:36][CH3:1])=[O:35])([CH2:25]3)[CH2:23]1)[CH2:29]2)([OH:21])=[O:20]