Ammonia → 3-(Methoxycarbonyl)adamantane-1-carboxylic acid

HRID 1296365ノート

反応式

HRID 1296365 の反応式
[C:1]([C:4]12[CH2:13][C:8]3(O)[CH2:9][CH:10]([CH2:12][C:6]([C:15]([OH:17])=[O:16])([CH2:7]3)[CH2:5]1)[CH2:11]2)(O)=O.N.[C:19]([C:22]12[CH2:32][C:26]3(O)[CH2:27][C:28](O)([CH2:30][C:24]([C:34]([OH:36])=[O:35])([CH2:25]3)[CH2:23]1)[CH2:29]2)([OH:21])=[O:20].NN.N(C(C12CC3(O)CC(O)(CC(C(NN)=O)(C3)C1)C2)=O)N.[CH3:59][N:60]([CH3:74])[C:61](C12CC3CC(CC(O)(C3)C1)C2)=[O:62].[Cl-].CNC>>[CH3:59][N:60]([CH3:74])[C:61]([C:8]12[CH2:13][CH:4]3[CH2:11][CH:10]([CH2:12][C:6]([C:15]([O:17][CH3:19])=[O:16])([CH2:5]3)[CH2:7]1)[CH2:9]2)=[O:62].[C:19]([C:22]12[CH2:32][CH:26]3[CH2:27][CH:28]([CH2:30][C:24]([C:34]([O:36][CH3:1])=[O:35])([CH2:25]3)[CH2:23]1)[CH2:29]2)([OH:21])=[O:20]

参加物

10

反応物 8

HCID 222AmmoniaHCID 312ChlorideHCID 674DimethylamineHCID 9321HydrazineHCID 120106445-Hydroxy-1,3-adamantanedicarboxylic acidHCID 120704631,3-Dicarboxy-5,7-adamantanediolHCID 120704711-(N,N-dimethylcarbamoyl)-3-adamantanolHCID 177806841,3-Di(hydrazinocarbonyl)-5,7-adamantanediol

生成物 2

HCID 3652223-(Methoxycarbonyl)adamantane-1-carboxylic acidHCID 184104771-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane

実験手順

For example, reaction of 1,3-dicarboxy-5-adamantanol with ammonia provides 1,3-dicarbamoyl-5-admatanol. Reaction of 1,3-dicarboxy-5,7-adamantanediol with hydrazine forms 1,3-di(hydrazinocarbonyl)-5,7-adamantanediol, etc. 1-(N,N-dimethylcarbamoyl)-3-adamantanol can be obtained by acting thyonyl chloride on 1-carboxy-3-adamantanol followed by reacting the resultant compound with dimethylamine. Similarly, 1-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane can be formed from 1-carboxy-3-methoxycarbonyladamantane,

後処理

  1. customprovides 1,3-dicarbamoyl-5-admatanol
  2. customcan be obtained

出典と根拠

ORDレコード
ord-e86830847fe746a4b465f2229ec6e9f9
出典データセット
uspto-grants-2007_07
特許番号
USRE039744E1

反応ノート

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